Why a proximity-induced Diels-Alder reaction is so fast.
نویسندگان
چکیده
Unlike normal Diels-Alder reactions of acyclic alkadienes with alkenes, the vinylbicyclo[2.2.2]octene employed in the Baran total synthesis of vinigrol undergoes a quantitative Diels-Alder reaction with a tethered alkene at room temperature. Density functional theory calculations reveal that this unprecedented reactivity originates from a combination of preorganization, diene strain, and tether stabilization.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 14 12 شماره
صفحات -
تاریخ انتشار 2012